More than a third of approved pharmaceutical drugs target G protein-coupled receptors (GPCRs). One receptor belonging to this family, GPR139, is highly expressed in the habenula -- a brain region with

Several effective medications are now available for treating opioid use disorder but many patients who could benefit do not receive them. Some patients who receive the medications face challenges to staying

Two weeks ago, nearly 6,000 of you (the most ever!) descended on Houston, Texas for the incredible 2018 NADCP Annual Training Conference featuring Vet Court Con. While it's impossible to convey just

The behaviour of rats that chose alcohol had several similarities to the diagnostic criteria that are used for alcohol addiction in humans, for instance continued use despite negative consequences. This was

This clinical trial:

  • Found that patients who self-administered cognitive behavioral therapy (CBT) using computerized training modules reduced their drug use as much as patients who received clinician-delivered CBT, and they

By: Captain Chideha Ohuoha, M.D., M.P.H., Director, SAMHSA Center for Substance Abuse Treatment
One hundred fifteen Americans die every day from opioid overdose. Whether a person deliberately misuses a prescription opioid

Binge drinking during adolescent development can have long-lasting effects in the brain, and recent data shows that these effects may directly impact first-generation offspring. These observations could have consequences for human

In comparison, current U.S. guidelines recommend no more than 2 drinks per day for men and no more than 1 drink per day for women.

Even light-to-moderate levels of alcohol intake

"Sleep is a serious problem for alcoholics," said Mahesh Thakkar, PhD, professor and director of research in the MU School of Medicine's Department of Neurology and lead author of the study.

This study found that:

  • In rats, co-administration with nalfurafine reduced the dose of oxycodone required to lower pain responses in models of human chronic pain.
  • The combination treatment generated

The prefrontal cortex (PFC) and the behavior-management abilities it supports -- both of which continue to mature throughout the teenage years -- are particularly vulnerable to the effects of heavy alcohol

By: Elinore F. McCance-Katz, M.D., Ph.D., Assistant Secretary for Mental Health and Substance Use
Capt. Ohuoha with American flag and white background
Capt. Chideha Ohuoha, M.D., M.P.H

It is my pleasure to announce

This study:

  • Demonstrated that a novel compound alleviates inflammatory and neuropathic pain in mice without producing tolerance or signs of abuse liability.
  • Supports the hypothesis that compounds that act